Volkova T., Bagina U. Ecological aspects of the multidrug resistance to chemotherapy agents // Principy èkologii. 2012. № 2. P. 4‒21. DOI: 10.15393/j1.art.2012.921


Issue № 2

Analytical review

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Ecological aspects of the multidrug resistance to chemotherapy agents

Volkova
   Tatyana
Petrozavodsk State University, VolkovaTO@yandex.ru
Bagina
   Ulyana
Petrozavodsk State University, lepsya@mail.ru
Keywords:
multidrug resistance
cancer cell lines
Р-glycoprotein
glutathione-S-transferase
chemotherapeutic agents
Summary: This paper presents generalized and analyzed literature data concerning the main mechanisms of the development of multidrug resistance (MDR) produced by tumour cells to chemotherapeutic agents. The conclusion is made about the biological role of acquired MDR phenotype for the tumour cell population.

© Petrozavodsk State University

Reviewer: I. Malysheva
Received on: 10 June 2012
Published on: 25 November 2013

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