Kudyasheva A., Zagorskaya N. The relationship between individual indicators of phospholipids composition in the liver of tundra voles living in the conditions of increased radioacivity // Principy èkologii. 2018. № 2. P. 75‒86. DOI: 10.15393/j1.art.2018.6742


Issue № 2

Original research

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The relationship between individual indicators of phospholipids composition in the liver of tundra voles living in the conditions of increased radioacivity

Kudyasheva
   Alevtina Grigor
D.Sc., Institute of Biology, Komi Scientific Center, Ural Division RAS, kud@ib.komisc.ru
Zagorskaya
   Nadezhda Gavrilovna
Institute of Biology, Komi Scientific Center, Ural Division RAS, zagorskya@ib.komisc.ru
Keywords:
Increased level of radioactivity
population phase
Microtus Oeconomus
liver
relationship between phospholipid fractions
Summary: Lipid peroxidation plays an important role in the adaptation of animals to environmental pollution with radionuclides. We studied some mechanisms of cellular metabolism regulation in in tunra voles living in the conditions of environmental radioactive pollution (the Komi Republic, Ukhta region) in different periods of population size (peak and decline phase). By the comparative biochemical analysis, we established that the character and tendency of interlinks between the major and minor fractions of phospholipids and total composition of liver phospholipids depended on physicochemical parameters of lipids. These differences depended on a population cycle phase and the radioactivity level of a particular plot, the severity of which was due to initial lipid peroxidation parameters and the degree of lipid unsaturation in a study tissue. The correlation coefficient between the compared fractions of phospholipids increased with the enhancement of pollution observed in both phases (pick and decline). Technogenic radioactive pollution of the radium plot provides the modification of lipid bi-layer properties of liver cell membranes, changes their physicochemical properties, in some cases destructed interrelation between normally coordinated parameters, and provides adaptation at the cell level. Intrapopulation factors have a modifying effect on the intensity of some links of the liver lipid peroxygenation in tundra voles. The noted features of the regulation system of lipid peroxidation in the liver of tundra voles are not specific and typical only for the impact of radiation. They can also occur under the influence of low intensity factors of physical and chemical nature.

© Petrozavodsk State University

Received on: 21 July 2017
Published on: 30 June 2018

References

Aleksahin R. M. Arhipov N. P. Barhudarov R. M. Vasilenko I. Ya. Drichko V. F. Ivanov Yu. A. Maslov V. I. Maslova K. I. Nikiforov V. S. Polikarpov G. G. Popova O. N. Sirotkin A. N. Taskaev A. I. Testov B. V. Titaeva N. A. Fevraleva L. T. Heavy natural radionuclides in the biosphere: Migration and biological effects on populations and biogeocenoses. M.: Nauka, 1990. 368 p.

Biological membranes. Methods. M.: Mir, 1990. 339 p.

Brin E. F. Travin S. O. Modeling of the mechanisms of chemical reactions. of Russia, Himicheskaya fizika. 1991. T. 10. P. 830–837.

Burlakova E. B. Alesenko A. V. Molochkina E. M. Pal'mina N. P. Hrapova N. G. Bioantioxidants in radiation injury and malignant growth. M.: Nauka, 1975. 211 p.

Drogovoz S. M. Derimedved' L. V. Study of the effect of exogenous superoxide dismutase on the course of model pathology of the liver, Vestnik nauchnyh issledovaniy. 1995. No. 5. P. 1–5.

Gribanov G. A. Features of structure and biological role of lysophospholipids, Voprosy medicinskoy himii. 1991. T. 37. No. 4. P. 2–10.

Hrustova N. V. Kozlov M. V. Shishkina L. N. The effect of physico-chemical properties of lipids in the liver of mice on the relationship between indicators of their composition, Biofizika. 2011. T. 56. No. 4. P. 668–672.

Ivashkin V. T. Drapkina O. M. Korneeva O. N. Clinical variants of metabolic syndrome. M.: OOO Izd-vo «Medicinskoe informacionnoe agentstvo», 2012. 216 p.

Keyts M. Technique of lipidology. M.: Mir, 1975. 322 p.

Klimovich M. A. Kozlov M. V. Hrustova N. V. Shishkina L. N. Influence of lipid characteristics on the age changes of the interrelation in the metabolic regulatory system of the laboratory animal tissues, Uspehi gerontologii. 2010. T. 23. No. 3. P. 427–429.

Kozlov M. V. Kushnireva E. V. Urnysheva V. V. Taran Yu. P. Shishkina L. N. The impact of lipid characteristics on the regulation of biochemical processes in the liver and blood of animals, Biofizika. 2007. T. 52. No. 4. P. 693–699.

Kozlov M. V. Shishkina L. N. Influence of damaging factors of different nature on the composition of liver lipids in mice, Radiacionnaya biologiya. Radioekologiya. 2008. T. 48. No. 3. P. 349–355.

Kudyasheva A. G. Shishkina L. N. Shevchenko O. G. Bashlykova L. A. Zagorskaya N. G. Biological effects of radioactive contamination in rodent populations. Ekaterinburg: UrO RAN, 2004. 214 c.

Kudyasheva A. G., Shishkina L. N., Shevchenko O. G. et al. Biological conseguences of increased natural radiation background for Microtus oeconomus Pall. Populations, J. Environ. Radioactivity. 2007. Vol. 97. P. 30–41.

Lakin G. F. Biometry. M., 1990. 352 p.

Maslov V. I. The radiation environment of dwellings and shelters of rodents in the conditions of ecosystems of high natural radioactivity, Radioekologicheskie issledovaniya v prirodnyh biogeocenozah. M.: Nauka, 1972. P. 216–226.

Men'schikova E. B. Lankin V. Z. Zenkov N. K. Bondar' I. A. Krugovyh N. F. Trufakin V. A. Oxidative stress. Pro-oxidants and antioxidants. M.: Firma «Slovo», 2006. 556 p.

Olenev G. V. Age determination in collomorphic rodents, functional-ontogenetic determination, environmental aspects, Ekologiya. 2009. No. 2. P. 103–115.

Raskosha O. V. Ermakova O. V. The morphological status of the thyroid gland of voles-housekeepers living in the conditions of high level natural radioactivity, Teoreticheskaya i prikladnaya ekologiya. 2013. No. 2. P. 55–61.

Shevchenko O. G. Zagorskaya N. G. Shishkina L. N. The relationship of the composition of phospholipids and physical-chemical characteristics in the tissues of the vole-housekeeper Microtus oeconomus Pall. different ages, Zhurnal evolyucionnoy biohimii i fiziologii. 2010. T. 43. P. 297–303.

Shilova S. A. Population organization of mammals under anthropogenic impact, Uspehi sovremennoy biologii. 1999. T. 119. No. 5. P. 487–503.

Shishkina L. N. Klimovich M. A. Kozlov M. V. A new approach to the analysis of the participation of oxidative processes in the regulation of metabolism in animal tissues, Biofizika. 2014. T. 59. Vyp. 2. P. 380–386.

Shishkina L. N. Kudyasheva A. G. Zagorskaya N. G. Shevchenko O. G. Taskaev A. I. Participation of processes of lipid peroxidation in the adaptation mechanism of mouse rodents to radioactive contamination in the Chernobyl NPP zone, Radiacionnaya biologiya. Radioekologiya. 2011. T. 51. No. 1. P. 185–200.

Shishkina L., Men'shov V., Brin E. Prospects of utilization of the model system of methyloleate oxidation for studies of kinetic properties of lipids , Biology Bulletin. 1996. Vol. 23. No. 3. P. 240–244.

Stuart J. A., Maddalena L. A., Merilovich M., Robb E.L. A midlife crisis for the mitochondrial free radical theory of aging, Longev. Healthspan. 2014. Apr. 1. Vol. 3 (1). P. 4. Doi: 10.1186/2046-2395-3-4.

Testov B. V. Taskaev A. I. The concentration of radioactive emanations in the burrows of small rodents in the areas with high natural radioactivity, Materialy radioekologicheskih issledovaniy v prirodnyh biogeocenozah. Syktyvkar, 1971. P. 65–76.

Zenkov N. K. Lankin V. Z. Men'shikova E. B. Oxidative stress. Biochemical and pathophysiological aspects. M., 2001. 343 p.

Zhukova A. G. Free radical oxidation and the mechanisms of intracellular protection in adapting to changes in the level of oxygen: An experimental study, Nauchno-issled. in-t obsch. patologii i patofiziologii RAMN. M., 2005. 47 p.

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