Platonova E., Golubev D., Zemskaya N., Timusheva N., Pakshina N., Mikhailova D., Patov S., Shaposhnikov M., Moskalev A. Comprehensive study of the adaptogenic and insecticidal potential of the extract of aronia Michurinii leaves (×Sorbaronia mitschurinii) on the Drosophila melanogaster model // Principy èkologii. 2025. № 3. P. 3‒2. DOI: 10.15393/j1.art.2025.16242


Issue № 3

Original research

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Comprehensive study of the adaptogenic and insecticidal potential of the extract of aronia Michurinii leaves (×Sorbaronia mitschurinii) on the Drosophila melanogaster model

Platonova
   Elena Yuryevna
Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Russia Komi Republic Syktyvkar Kommunisticheskaya St., 28, Dega37@yandex.ru
Golubev
   Denis Anatolyevich
Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Russia Komi Republic Syktyvkar Kommunisticheskaya St., 28, denismeatboy@gmail.com
Zemskaya
   Nadezhda Vladimirovna
Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Russia Komi Republic Syktyvkar Kommunisticheskaya St., 28, zemskaya@ib.komisc.ru
Timusheva
   Natalia Sergeevna
Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Russia Komi Republic Syktyvkar Kommunisticheskaya St., 28, uliasheva.n.s@ib.komisc.ru
Pakshina
   Natalya Rishatovna
Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Russia Komi Republic Syktyvkar Kommunisticheskaya St., 28, pakshina.n.r@ib.komisc. ru
Mikhailova
   Daria Vladimirovna
Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Russia Komi Republic Syktyvkar Kommunisticheskaya St., 28, kukuman@ib.komisc.ru
Patov
   Sergey Alexandrovich
PhD, Institute of Chemistry of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 167000 Russia Komi Republic Syktyvkar Pervomayskaya St., 48.,, ser-patov@yandex.ru
Shaposhnikov
   Mikhail Vyacheslavovich
PhD, Associate Professor, Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, 16798 Russia Komi Republic Syktyvkar Kommunisticheskaya St., 28, shaposhnikov@ib.komisc.ru
Moskalev
   Aleksey Alexandrovich
DSc, Professor, Corresponding Member of the Russian Academy of Sciences, B.V.Petrovsky Institute of Longevity with a Clinic of Rehabilitation and Preventive Medicine the Russian Scientific Center of Surgery, 119435 Russia Moscow, amoskalev@list.ru
Keywords:
extract of aronia Michurin leaves
stress resistance
plant insecticides
adaptation
Drosophila melanogaster
Summary: The fruits of black chokeberry, represented by the species Aronia melanocarpa and ×Sorbaronia mitschurinii, are widely distributed throughout the world as a source of a wide range of biologically active substances, macro- and micro-molecules. Although, there is little data on the study of leaves, especially on their possible toxic effects on the viability of model organisms. We analyzed the composition of the extract of aronia Michurin leaves, which showed the presence of flavonoids and phenolic compounds in it, including gallic acid, rutin (rutoside, vitamin P), isoquercetin, and kaempferol. The addition of leaf extract throughout the lifespan, at 1-2 and 4-5 weeks, resulted in a reduction in lifespan of individuals of both sexes of Drosophila melanogaster. The leaf extract had no statistically significant effect on the functional integrity of the intestinal barrier in both sexes of fruit flies. There were also no adverse effects on the motor activity of fruit flies. The study showed that pre-feeding with the extract as part of a nutrient medium resulted in a 15 % increase in the median survival rate of males under fasting conditions at a young age and a 6 % increase in the survival rate of females under the same conditions at an adult age. However, under hyperthermia conditions, pretreatment with the extract reduced the survival rate of males at 10 days (by 12 %) and 33 days (by 20 %), as well as decreased the survival rate of females at 33 days (by 12 %). In addition, leaf extract of aronia Michurin reduced the expression of genes associated with lipid metabolism (lip3), insulin signaling (ilp5) in both sexes of Drosophila melanogaster. This may indicate the effect of extract on energy homeostasis and the signaling pathway of insulin in the body. Further research on the biological effects of extract of aronia Michurin leaves may contribute to the development of a natural insecticide that does not have a detrimental effect on the environment.

© Petrozavodsk State University

Received on: 10 June 2025
Published on: 01 October 2025

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